However, of the 35 up-regulated proteins in the GG2, two (TGFB1 and FLNA) are involved in androgen receptor pathways, three (FLNC, DES, and LMOD1) have previously been associated with better prognosis in PCa (25, 41, 42, 43, 44, 45), four (PRKCA, ACTN1, AOC3, and LDHB) are targets for FDA-approved drugs (39), and three (MYLK, FLNA, and FLNC) are potential drug targets (39). Here, DES is linked to posterior cortical atrophy.