In our study, we demonstrated that the main inflammatory pathway associated to cachexia (IL-6-STAT3 axis) upregulates the BMP signaling inhibitor Erfe in atrophic skeletal muscles, leading to a condition of BMP resistance that can contribute to the catabolic effects of the hyper-active activin/TGFβ-Smad2/3 signaling. This evidence concerns the gene ERFE and Cachexia.