Subsequently, we explored which molecular mechanism could trigger the transcriptional up-regulation of the BMP inhibitors Erfe and Fkbp12 in cachexia by performing chromatin immunoprecipitation (ChIP-qPCR) assay on atrophic C2C12 myotubes treated with C26 CM and on cachectic skeletal muscles of C26 tumor-bearing mice (Figure 1H). This evidence concerns the gene ERFE and neoplasm.