High levels of ALT (p < 0.001), AST (p < 0.001), ALP (p < 0.001), CRP (p < 0.001), ESR (p < 0.001), FBS (p = 0.043) and creatinine (p < 0.001) and low levels of TG (p = 0.005), LDL (p < 0.001), uric acid (p < 0.001), real-time PCR Ct value (p = 0.008),and 25-hydroxyvitamin D (p < 0.001) were strongly linked with the severity of COVID-19. This evidence concerns the gene CRP and COVID-19.