We found that knockout of Zdhhc7 significantly blunted the c-Myc/MCL1 induced HCC, and this inhibition of tumorigenesis was associated with decreased S-palmitoylation and phosphorylation of STAT3 and decreased HIF1α abundance in tumors, consistent with our in vitro data. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.