Although it has been observed that the palmitoylation-depalmitoylation cycle induced by DHHC7 and APT2 is important for STAT3 activation cycles in Th17 cells(1), our data suggested that S-palmitoylation-related genes of STAT3 were positively correlated with ZDHHC7 but not LYPLA2 in HCC. Here, STAT3 is linked to hepatocellular carcinoma.