Furthermore, CXCL13+ FBs may further promote inflammatory responses through the expression of a wide range of cytokines and chemokines, including the neutrophil chemokines CXCL1, CXCL2, and CXCL8 (Supplemental Figure 8, E and F), which in turn may promote NETosis, a prominent feature of HS inflammation (37, 45). This evidence concerns the gene CXCL8 and histiocytic sarcoma.