WWTR1 and pulmonary fibrosis: Indeed, in addition to well-known profibrotic markers such as TGF-β and angiotensinogen (AGT, which has previously been identified as a critical component in cardiac and pulmonary fibrosis; refs. 21, 25), we identified several factors belonging to the Hippo pathway (YAP1, WWTR1, and TEAD2), particularly among the SFRP4+ myofibroblasts (Figure 6D and Supplemental Figure 9A).