Healthy controls and kidney disease samples showed strong expression of DNL genes, including ACSS2, NR1H3 (liver X receptor α [LXRA]), NR1H4 (farnesoid X receptor [FXR]), SREBF1, SCAP, PLIN2, PLIN5, ACACAB, ATP citrate lyase (ACLY), and FASN in PT cells and some other tubule cells (Figure 7, A and B). Here, NR1H3 is linked to kidney disorder.