Overexpressionof TROAP was reported in glioblastoma cells resulting in promotingcell proliferation via the Wnt/β-Catenin signaling pathway,58 while in hepatocellular carcinoma, TROAP overexpressionled cells to accumulate in the G1/S phase and to enhanced cell proliferationthrough direct interaction with dual specificity tyrosine phosphorylationregulated kinase 1 A/B (DYRK1A/B).59 Theoverexpression of CDKN1A and TROAP might be attributed to M2 polarization,where microglial cells increase proliferation and are involved inimmune responses, tissue repair, and tissue remodeling.60 Here, DYRK1A is linked to hepatocellular carcinoma.