CDKN1A and hepatocellular carcinoma: Overexpressionof TROAP was reported in glioblastoma cells resulting in promotingcell proliferation via the Wnt/β-Catenin signaling pathway,58 while in hepatocellular carcinoma, TROAP overexpressionled cells to accumulate in the G1/S phase and to enhanced cell proliferationthrough direct interaction with dual specificity tyrosine phosphorylationregulated kinase 1 A/B (DYRK1A/B).59 Theoverexpression of CDKN1A and TROAP might be attributed to M2 polarization,where microglial cells increase proliferation and are involved inimmune responses, tissue repair, and tissue remodeling.60