Apoptosis, a programmedcell death, plays an essential role inboth physiological and pathological processes in many human tissuessince the defects in the regulation of this pathway potentially leadto many diseases, including glioblastoma.52 Observed increased apoptosis can be attributed to the Dox intercalationin the DNA, which stimulates p53 tumor suppressor protein expressionand leads to programmed cell death.53 This evidence concerns the gene TP53 and glioblastoma.