After the intervention of TLR7 agonist imiquimod, SLE model mice and Tfh cells significantly decreased BCL-6 mRNA expression and upregulated PRDM1 (encoding Blimp-1) and STAT5b mRNA expression, and the number of Tfh cells and GC B cells were significantly reduced, while the anti-double-stranded DNA (anti-dsDNA) antibody and antinuclear antibody titers in serum were also significantly decreased [36]. The gene discussed is PRDM1; the disease is systemic lupus erythematosus.