Although our study was designed and executed before the publication of the HISTALDO consensus, our histopathological analysis was generally consistent with this consensus except for the small difference in the definition APA, which in our study was a solitary CYP11B2-positive neoplasm ≥7 mm in diameter, and accordingly the definition of APN, which in our study was a round CYP11B2-positive nodule <7 mm in diameter whereas the cutoff in HISTALDO study was 10 mm (8). The gene discussed is CYP11B2; the disease is neoplasm.