For example, Cao et al. reported the significance of FGFR-PI3K and FGFR-ERK signaling in AQP3 expression in breast cancer.38 Zhang et al. also suggested that AQPs regulated PI3K/AKT pathway activity in the expression and regulation of placenta and fetal membranes.39 In our study, we found that RGP could significantly inhibit the activation of the PI3K/Akt pathway, while the inhibitory effect of RGP on the PI3K/Akt pathway was significantly limited after overexpression of AQP3. The gene discussed is AQP3; the disease is breast cancer.