To evaluatethe synthetic ssRNA-binding peptide’s affinity for biologicallyderived RNA targets, we have chosen two cytosine-rich RNA motifs fromthe oncogenic Cdk6 3′UTR RNA and MYU lncRNA.These motifs have previously been identified as targets of hnRNPK,45 and they both consist of extended cytosine repeats(>4 nt) within a necessary single-stranded region for the progressionof colon cancer cells. Here, CDK6 is linked to colonic neoplasm.