Figure 5A shows that KRB-456 inhibited the viability of Panc0203 and Panc1 cells in a concentration-dependent manner with IC50 values of 4.9 ± 0.7 μmol/L and 14.8 ± 2.7 μmol/L, respectively. Similar IC50 values were obtained with other pancreatic cancer cell lines including one that harbors KRAS G12D (Panc0403 cells, IC50 = 12.61 μmol/L), KRAS G12V (Capan1 cells, IC50 = 10.46 μmol/L), KRAS G12C (MiaPaCa2, IC50 = 12.68 μmol/L), and KRAS WT (BxPc3 cells, IC50 = 11.83 μmol/L; Supplementary Fig. S6). Here, KRAS is linked to familial pancreatic carcinoma.