RAF1 and familial pancreatic carcinoma: In summary, we report here on the discovery of a novel natural product-inspired small molecule, KRB-456, that binds a dynamic allosteric binding pocket within the switch-I/II region of KRAS G12D, suppresses the levels of KRAS bound to GTP and inhibits the binding of KRAS to RAF1 in human pancreatic cancer cells that harbor KRAS G12D.