KRAS and familial pancreatic carcinoma: Indeed, although in ITC in vitro assays using purified KRAS proteins, KRB-456 binds to KRAS G12D with 1.5-, 2-, and 6-fold higher affinity than to KRAS G12V, KRAS WT, and KRAS G12C, respectively, its potency to inhibit cell viability of pancreatic cancer cell lines harboring KRAS G12D, KRAS G12V, KRAS WT, and KRAS G12C were similar with IC50 values ranging from 5 to 15 μmol/L (see Results section).