KRAS and familial pancreatic carcinoma: To this end, we used fresh biopsies from 4 patients with pancreatic cancer, 3 patients (G166, G148, and G160) whose tumors harbor KRAS G12D mutations, and 1 patient (G174) whose tumor harbors KRAS G12V mutation (see Materials and Methods section for patients age, sex, tumor pathology, staging, and patient treatments).