IL6 and benign prostatic hyperplasia: LPS was responsible for the upregulation of YAP1 in Kupffer cells, and the YAP1‐TEAD complex promoted the production of pro‐inflammatory mediators (MCP‐1, TNF‐α, and IL‐6) and pro‐fibrotic molecules (α‐SMA, collagen I).[26] The present study showed that YAP1 expression was significantly increased in the prostate of the EAP model rats and the inflamed‐BPH patients.