ACA: anterior cerebral artery, ACE-I: angiotensin-converting enzyme inhibitor, ACoA: anterior communicating artery, AED: antiepileptic drug, ARB: angiotensin II receptor blocker, GBM: glioblastoma, ICA-PCoA: internal cerebral artery-posterior communicating artery, MCA: middle cerebral artery, N/A: not applicable, UIA: unruptured intracranial aneurysm. The gene discussed is ACE; the disease is glioblastoma.