Echocardiogram (ECG): Detailed examination of the heart's functionality and valve conditions to check for signs of heart failure. Thyroid hormone blood test: Measure levels of T3, T4, and TSH to get a detailed assessment of the thyroid function. Renal function tests: Conduct BUN, creatinine, and urinalysis to determine renal status. Doppler ultrasound of the lower limbs: To check for potential circulatory issues in the veins as a cause of the swelling. Lifestyle guidance: Advise on salt intake restriction, appropriate hydration, and elevating the feet during rest. The gene discussed is TG; the disease is heart failure.