CD274 and neoplasm: The major drawbacks are that (i) mannosylation of therapeutic IgG antibodies increases their serum clearance by mannose receptors (Goetze et al., 2011); (ii) classical plant CCD epitopes can lead to host antibody reactivity (Nkurunungi et al., 2021); and (iii) lack of core fucose can significantly enhance antibody ADCC against PD‐L1‐positive non‐tumour cells (Yamane‐Ohnuki and Satoh, 2009).