It has been shown that the steric hindrance of PD‐L1 glycosylation significantly affects antibody recognition, with implications in patient therapeutic stratification (Lee et al., 2019).Therefore, we next evaluated the ability of plant‐derived DL variants to bind to cell surface PD‐L1 expressed by two gastrointestinal cancer cells upon in vitro interferon gamma (IFNγ) stimulation: the metastatic gastric carcinoma cell line NCI‐N87 and the colorectal carcinoma cell line SW48. Here, IFNG is linked to gastric carcinoma.