Luo et al designed a randomized controlled trial to observe the effect of acupoint catgut embedding (Feishu, Pishu, Sanjiaoshu, Mingmen, Bladder Shu, Shanzhong, Zhongwan, Qihai, Tianshushuang, Zusanli and Xuehai) on NPY and adiponectin (ADP) in patients with simple obesity.[72] The 58 cases of obesity were randomly divided into a catgut embedding therapy group (28 cases) and a Western medicine group (30 cases). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.