Guglielmi et al showed that central adiposity could affect regional cardiac hypertrophy in patients with HCM.[33] For the first time, to the best of our knowledge, our data shows links between HCM and genes including MGST1, LYPLAL1, and GATM, which may provide a new way to improve our understanding of HCM development. This evidence concerns the gene GATM and cardiac hypertrophy.