The important role of the ErbB family in heart morphogenesis through interaction with the extracellular environment has been well demonstrated.[34] Previous studies have shown that the GnRH pathway is involved in the development of cardiomyopathies.[35] Toll-like receptors, as key factors that regulate innate immune responses, can lead to acute and chronic inflammation.[36] Inflammation is a characteristic feature of cardiac hypertrophy and mediates the important roles of toll-like receptors in the HCM process. This evidence concerns the gene GNRH1 and cardiomyopathy.