TF and early-onset autosomal dominant Alzheimer disease: Although the role of TOMM40 in HCM has not been reported, TOMM40 is a candidate gene that causes mitochondrial dysfunction in late-onset Alzheimer’s disease.[31] Moreover, in the mRNA-TF-miRNA network, TOMM40 was associated with the regulation of multiple genes, suggesting a relatively important role of this gene in HCM.