Quercetin and its derivatives have demonstrated extensive pharmacological effects, including anti-inflammatory, antiviral, and antioxidant activities.[47] Previous studies have shown that quercetin supplementation can significantly reduce inflammatory factors such as IL-6 and TNF-α expression in Zucker diabetic fatty rats with type 2 diabetes.[48] In a lipopolysaccharide-induced colitis mouse model, quercetin improved intestinal inflammation effectively caused by lipopolysaccharide and reduced the expression levels of inflammatory factors IL-6 and IL-12.[49]. This evidence concerns the gene TNF and type 2 diabetes mellitus.