The anti-inflammatory cytokine IL10 was strongly associated with IL6 and TNF in the PPI network,[34,35] and IL6 and IL10 were critical factors related to fatal COVID-19.[36] GO and KEGG analyses indicated that TNF, IL6, and IL10 played essential roles in the COVID-19 signaling pathway (Fig. 6). The gene discussed is IL10; the disease is COVID-19.