Bone formation requires an involvement of angiogenesis not only for it provides essential oxygen, nutrients and bone cells,[41] but also for its directly angiogenesis-osteogenesis coupling.[42,43] In contrast, reduction of angiogenesis genetically or pharmacologically is an important pathogenesis to many bone diseases, such as fracture ununion, femoral head necrosis and osteoporosis.[44] VEGFA and EGF were 2 hub therapeutic targets of Lycii Fructus. Here, EGF is linked to osteoporosis.