Astrocytes can also use mechano-gated Piezo1 channel-mediated mechanotransduction mechanisms to robustly regulate adult neurogenesis and cognitive function.[65] In AD, Aβ stimulates NF-κB and complement signaling in astrocytes, inducing the synthesis of inflammatory mediators (IL-1, C1q, and TNF-α) in astrocytes, impairing synaptic density and dendritic morphology.[66]. The gene discussed is TNF; the disease is Alzheimer disease.