CD274 and cancer: Studies on tumors have suggested that the effectiveness of anti-PD-L1 treatment is related to the expression of PD-L1 in tumor tissues and infiltrating cells within the tumor stroma.[13–15] Nevertheless, the therapeutic impact of PD-1/PD-L1 in various cancers remains a subject of debate.[16–19] Thus, it is important to investigate the patterns of PD-L1 expression and tumor-infiltrating immune cells (TIICs) and their correlation with patient prognosis.