PECAM1 and neoplasm: Studies have highlighted the importance of angiogenesis in tumor growth and metastasis, and CD31 is involved in the process of cell migration and angiogenesis.[49,50] Mice xenografted with cells overexpressing CD31 displayed significantly shorter survival.[50] Studies have shown that angiogenesis is necessary for tumor growth and metastasis.[51] These findings strongly support the inhibition of tumor angiogenesis by targeting CD31.