EDN1 and Hypertension: Moreover, studies have revealed the potential involvement of both NO and ET in regulating the circadian rhythm of blood pressure.[13,14] Relevant studies have shown that Liuzijue exercise can upregulate plasma NO levels in patients with hypertension by enhancing the NO release pathway.[12] Furthermore, it effectively reduces the levels of ET-1 in patients, subsequently diminishing its vasoconstrictive effect while improving blood pressure.[15] Therefore, Liuzijue exercise can promote restoration of the normal circadian rhythm of blood pressure.