FAM89A appears to be related to the immune response, and 2 previous studies indicated that the expression levels of the FAM89A gene could be used to differentiate bacterial from viral infections in the early phase, with a lower expression observed in viral infections and a higher expression observed in bacterial infections.[20,21] Moreover, studies have found that the expression of FAM89A is increased in children with sepsis, which is consistent with our findings.[22] However, the specific biological role of FAM89A in sepsis and its underlying mechanisms remain unclear. This evidence concerns the gene FAM89A and viral infectious disease.