AKT1 and cardiac hypertrophy: FGF13 is an important regulator of mitochondrial homeostasis in the endothelium in diabetic nephropathy.[31] In addition, some studies have argued that FGF13 has important effects on abnormal glucose tolerance through the PI3K-AKT signaling pathway.[32] A study also considered that FGF13 potentiates pathological cardiac hypertrophy via the activation of NF-κB.[33]