Hepatocellular apoptosis is present during the early phases of human liver failure.[53] Apoptosis plays a critical role in the development of various liver diseases, such as cholestatic liver injury, alcoholic hepatopathy, diabetic hepatopathy, and drug-induced liver injury.[54] The P53-upregulated modulator of apoptosis (PUMA) holds significant importance in mitigating liver injury induced by APAP. The gene discussed is TP53; the disease is liver failure.