Both of these suggest that there are localized diffuse hemorrhage and fibrin thrombus in the myometrium of patients with adenomyosis We hypothesize that the exposure of endometrial vasculature due to curettage, the entry of fibrin thrombi and related coagulation factors such as tissue factor and fibrinogen into the circulation from microhemorrhagic foci, and surgical emergency (significantly elevation of CRP), contributed to abnormal coagulation function and hypercoagulable state of the body, further causing thrombosis or PE. This evidence concerns the gene CRP and adenomyosis.