FXR1 degradation mediated by Fbxo4 inhibits tumorigenesis in head and neck squamous cell carcinoma, while FXR1 regulates Fbxo4 expression by inhibiting protein translation in feedback.[9] FXR1 expression is elevated in nephroblastoma, and the expression level of FXR1 in nephroblastoma patients is 10 times that of the normal population. This evidence concerns the gene FXR1 and Wilms tumor.