XPO1 and malignant colon neoplasm: Several cancers have been linked to this gene, including ovarian carcinoma, colon cancers, and lung cancers.[34–36] In addition to inhibiting apoptosis, modulating signaling pathways, and responding to DNA damage, NCBP2 plays a critical role in cancer cell cycle regulation.[34] XPO1 is the exclusive exporter of various proteins that suppress tumor growth and regulate the cell cycle.