It is expressed in multiple normal tissues throughout the human body.[30] Studies have suggested that TARDBP may play a significant role in human tumorigenesis and has been detected in specific tumors like hepatocellular carcinoma and leukemia.[31,32] Research has demonstrated that TARDBP acts as a regulator of glycolysis in hepatocellular cancer cells. This evidence concerns the gene TARDBP and hepatocellular carcinoma.