FXR1 degradation mediated by Fbxo4 inhibits tumorigenesis in head and neck squamous cell carcinoma, while FXR1 regulates Fbxo4 expression by inhibiting protein translation in feedback.[9] FXR1 expression is elevated in nephroblastoma, and the expression level of FXR1 in nephroblastoma patients is 10 times that of the normal population. Here, FBXO4 is linked to Nephroblastoma.