HNF4A and gastric cancer: Additionally, a series of reports suggested a potential role of ITLN-1 in cancer development.[7–9,11,12,29,30] Li et al reported that ITLN-1 increases the level of hepatic nuclear factor 4α (HNF4α), thereby inhibiting the nuclear localization and transcriptional activity of β-catenin in gastric cancer cells.[12] They also found that high ITLN-1 levels were significantly associated with better outcomes in patients with gastric cancer.