ITLN1 and malignant colon neoplasm: However, the role and specific mechanisms of ITLN-1 in the development of malignant pleural mesothelioma are still unclear.[9,10] Other studies have shown that ITLN-1 can inhibit tumor progression and play the role of a tumor suppressor gene in neuroblastoma,[11] gastric cancer[12] and colon cancer.[13,14] Therefore, the role of ITLN-1 in different types of tumors remains controversial.