CASP8 and non-small cell lung carcinoma: Prabhu et al and others have shown that SAN can promote the expression of cleaved caspase-8 and stimulate mitochondrial apoptosis in non-small cell lung cancer.[12] Similarly, the present study experiments showed that SAN can increase the expression of cleaved caspase-8 in NPC cells, suggesting that SAN-induced apoptosis in NPC cells may be related to the mitochondrial pathway.