The results of PPI network topology analysis showed that the therapeutic effect of this drug on hepatitis was mainly achieved by regulating RELA, AKT1, JUN, MAPK1, TP53, CCND1, MYC, RB1, MAPK14, NFKBIA, CDKN1A, HIF1A, ESR1, and FOS. The gene discussed is MAPK14; the disease is hepatitis A virus infection.