The patient underwent radical surgery for left-sided breast cancer in 1975. 2014, she was seen for lymphedema of the left upper extremity, CT showed soft tissue growth on the left chest wall, and an invasive breast cancer was suggested by biopsy. immunohistochemistry confirmed strong positive ER and PR and negative HER2. Local recurrence of breast cancer was considered. The gene discussed is ERBB2; the disease is breast carcinoma.