ERBB2 and breast cancer: The patient had modified radical surgery mastectomy for right-sided breast cancer in 1991 and received 4 cycles of chemotherapy and tamoxifen for 5 yr after surgery. 2015, she presented with “facial edema and chest distress” and received 18F-FDG-PET/CT, which suggested increased FDG uptake in the right supraclavicular lymph nodes, mediastinum and sternum, and after biopsy, suggested Immunohistochemistry confirmed strong positive ER and PR and positive HER2, and local recurrence of breast cancer was considered.