EZH2 and neoplasm: Notably, Akt/NICD1/Control (A/N+C) mice showed a large tumour load in the liver, while Akt/NICD1/ Ezh2 knockdown (A/N+shEzh2#1, A/N+shEzh2#2) mice showed only a few small lesions in the liver after 5 weeks of plasmid injection (Figure 2H).