AKT1 and neoplasm: Akt/NICD1/Vector+GSK343 (A/N/V+GSK343) and Akt/NICD1/Ezh2+GSK343(A/N/E2+GSK343) mice developed a smaller tumour load 5 weeks after plasmid injection, while Akt/NICD1/Vector+Vehicle (A/N/V+Vehicle) and Akt/NICD1/Ezh2+Vehicle (A/N/E2+Vehicle) mice developed a greater number of large lesions in the liver (Figure 7H).