We hypothesize that this potential relationship might be caused by increased depression of hematopoietic tissue in advanced, metastatic PCA, because the dominant tumor lesion fraction was contributed mainly by osseous lesions in the higher-tumor quartiles, and there was a moderate negative correlation between bone PSMA-TV and hemoglobin levels (Fig. 3). The gene discussed is FOLH1; the disease is posterior cortical atrophy.