NFKB1 and chronic kidney disease: In a rodent model of CKD, the administration of the inhibiting compound pyrrolidine dithiocarbonate reduced renal interstitial fibrosis.56 The NF-κB inhibitor parthenolide decreased inflammation and renal injury in cisplatin-induced renal damage models57 and reduced renal inflammation in unilateral ureteric obstruction models.58 Parthenolide demonstrated antifibrotic effects in patients with DN59 and glomerulosclerosis.60