This analysis revealed that BSO markedly suppressed SNORA56-induced elevation of GCL enzyme activity (Fig. 5U), as well as SNORA56-driven proliferation and ferroptosis inhibition in HIEC cells (Fig. 5V–Y), indicating that SNORA56 promotes CRC tumorigenesis by enhancing GSH protein synthesis. Here, SNORA56 is linked to colorectal carcinoma.