GPT and familial pancreatic carcinoma: In a mouse model, the maternal smoking exposure during pregnancy increased the severity of non-alcoholic steatohepatitis in offspring mice by increasing their serum ALT, AST, total cholesterol, and triglyceride levels and modulating the phosphorylation of AMP-activated protein kinase [21]. Elucidation of the exact metabolic pathways between these biomarkers through which the smoking modulates can facilitate precision medicine or management for pancreatic cancer.