ZNF503 and familial pancreatic carcinoma: Other four notable SNPs (i.e., rs59519100, rs11164375, rs72805402, and rs55870181) were all associated with a higher risk of pancreatic cancer; rs59519100 showed a significant association with γ-glutamyl tyrosine, rs11164375 with lysoPE (18:0/0:0), rs72805402 (mapped to ZNF503) and rs55870181 with L-leucine; Manhattan plots for these are presented in Additional file 1: Figure S2.