In a mouse model, the maternal smoking exposure during pregnancy increased the severity of non-alcoholic steatohepatitis in offspring mice by increasing their serum ALT, AST, total cholesterol, and triglyceride levels and modulating the phosphorylation of AMP-activated protein kinase [21]. Elucidation of the exact metabolic pathways between these biomarkers through which the smoking modulates can facilitate precision medicine or management for pancreatic cancer. This evidence concerns the gene GPT and metabolic dysfunction-associated steatohepatitis.