Interestingly, 16 of the 34 components examined (47.1%) were altered and, in line with our Discovery cohort, KHDRBS1, NOVA1, PRPF8, SNW1, SRSF1, and SRSF9 were also overexpressed in tumor tissue in this external cohort (Additional file 1: Figure S1A). This evidence concerns the gene PRPF8 and neoplasm.