Furthermore, 36.8% (95% CI 16.5–57.2%) and 13.9% (95% CI 3.6–24.2%) of the inverse association between sports and CAD was mediated by VIM and LGALS2 (galectin-2), respectively, while the inverse association for vigorous physical activity was mainly mediated by CNP (49.9%), ARG1 (arginase-1; 27.2%) and AGER (11.3%). The gene discussed is AGER; the disease is coronary artery disorder.