Similarly, the positive association of WHR and VAT with CAD was mediated through PCSK9 (9.6% for WHR; 11.8% for VAT), RPS6KA1(9.6% for WHR; 8.8% for VAT), ITPKA (8.8% for WHR; 8.5% for VAT), ANGPTL4 (6.9% for WHR; 9.4% for VAT), and AGER (4.5% for WHR; 5.0% for VAT). This evidence concerns the gene ANGPTL4 and coronary artery disorder.