Additionally, we observed that ANGPTL4, RPS6KA1 (ribosomal protein S6 kinase A1), PCSK9, ITPKA (inositol-trisphosphate 3-kinase A), and AGER (advanced glycosylation end product-specific receptor) were each responsible for mediating 5 to 10% of the BMI-CAD association. Here, PCSK9 is linked to coronary artery disorder.