Besides, 33.5% (95% CI 20.5–46.6%), 9.9% (95% CI 4.7–15.2%), and 4.1% (95% CI 1.6–6.5%) of the association between caffeine consumption and CAD was mediated through APOB, VIM, and FAS (fatty acid synthase), respectively, while the association between coffee consumption and CAD was mainly mediated through MAP1LC3A (29.0%) and FAS (10.0%). The gene discussed is MAP1LC3A; the disease is coronary artery disorder.