To corroborate our findings and to confirm the functional relevance of PSMB8 in vivo, we injected equal numbers of PSMB8 depleted human AML cells into pre-conditioned (2 Gy, single dose irradiation) immuno-compromised mice (Fig. 1F, Supplementary Figure S1G). The gene discussed is PSMB8; the disease is acute myeloid leukemia.