This delay in disease development resulted in significantly prolonged survival (median survival of MA9-LMP7+/+: 63.0 days; MA9-LMP7−/−: 92.5 days; p = 0.0387) and 6/12 (50%) of animals failed to establish leukemia within 100 days of observation (Fig. 3B). This evidence concerns the gene PSMB8 and leukemia.