Here, catalytic subunits of the standard proteasome (PSMB5) and immunoproteasome (IP) PSMB8, PSMB9 and PSMB10 (corresponding to murine LMP7, LMP2 and LMP10) showed significantly higher expression in KMT2A-r AML (Fig. 1B) compared to non- KMT2A-r -AMLs. This evidence concerns the gene PSMB8 and acute myeloid leukemia.