However, the detection of specific immunity against HPV in HNSCC has shown a broad response of CD4 and CD8 T cells against viral antigens E1, E2, E4, E5, E6, E7, and L1 [64], and E1, E2 and E5 have been identified as major targets of intratumoral CD8 T cells [65, 66]. Here, CD8A is linked to head and neck squamous cell carcinoma.