Plasmodium vivax initiates blood-stage infections by invading immature red blood cells (RBCs) or reticulocytes using its endogenous Duffy binding protein (PvDBP) to access the Duffy antigen receptor for chemokines (DARC) (encoded by gene atypical chemokine receptor 1, ACKR1 [10–13]. The gene discussed is ACKR1; the disease is infection.