In contrast, MDD was significantly associated with neuroreceptor signaling, including “ganglioside metabolic process” and “negative regulation of dopamine receptor signaling pathway”, whereas IBD was enriched in processes related to cellular development and immune activation, such as “endothelial cell development”, “JAK-STAT cascade involved in growth hormone signaling pathway” and “positive regulation of interleukin-1 beta production” (Additional file 1: Fig. S12e-f). The gene discussed is IL1B; the disease is inflammatory bowel disease.