For CRC, BBR inhibits proliferation, invasion, and metastasis of CRC cells by downregulating the COX-2/PGE2-JAK2/STAT3 signaling pathway [18], the β-catenin signaling pathway [19], and the mammalian target of rapamycin (mTOR) pathway [20]. The gene discussed is STAT3; the disease is colorectal carcinoma.