In addition, FGF21 has been claimed to have beneficial regulatory effects on lipid metabolism and thermogenesis, especially in mice undergoing serious stresses such as starvation, cold exposure and hepatic steatosis (Mai et al. 2009; Inagaki et al. 2008; Fisher et al. 2012; Zhang et al. 2015). This evidence concerns the gene FGF21 and Hepatic steatosis.