We constructed the prognostic risk score for patients with hepatocellular carcinoma as follows: risk score = (0.3519) × PPM1G + (0.0637) × FKBP1A + (0.0673) × STAM + (0.0373) × MAD2L2 + (0.0031) × TBL1XR1 + (0.0172) × ANXA5. The gene discussed is TBL1XR1; the disease is hepatocellular carcinoma.