The immunohistochemical analysis revealed that the expression of ANXA5, TBL1XR1, MAD2L2, STAM, FKBP1A, and PPM1G in HCC tissues of 20 patients was significantly higher than that in adjacent normal liver tissues (Fig. 4A, B) and was mainly located in the cytoplasm with brown granules. Here, MAD2L2 is linked to hepatocellular carcinoma.