PDE4D and colorectal carcinoma: Higher genetically predicted levels of both ETS2 (OR [95% CI] = 0.99688 [0.99511, 0.99866]; P = 0.00058; FDR = 0.00667) and PDE4D (OR [95% CI] = 0.99817 [0.99694, 0.99939]; P = 0.00343; FDR = 0.02309) were linked to lower CRC risk.