Increased risk of CRC was associated with higher genetically predicted levels of both AKR1A1 (OR [95% CI] = 1.00142 [1.00068, 1.00216]; P = 0.00015; FDR = 0.00345) and CTF1 (OR [95% CI] = 1.0012 [1.00037, 1.00203]; P = 0.00446; FDR = 0.02309). The gene discussed is CTF1; the disease is colorectal carcinoma.