We found that SB3-12 efficiently solubilized AD-specific lipid species, putatively determining eight kinds of lipid classes, including acyl carnitine, fatty acids, lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylserine, NAE, NAT, and SPB, which led to clearer imaging of Aβ deposition in subcortical regions through improvement of antigen recovery in AD brain. Here, BRD2 is linked to Alzheimer disease.