GDF10 and lung cancer: Moreover, RUNX2 could recruit histone H3K9-specific methyltransferase Suv39h1 to BMP3B (GDF10) proximal promoter and then suppress the BMP3B expression, which is regarded as a tumor growth inhibitor and a gene silenced in lung cancers (Dai et al. 2004; Tandon et al. 2012).