The equivalent of the A3B-driven mutation in humans (Ptprs_mut1, D138N; Extended Data Fig. 3c) was identified in tumors of patients with lung, colorectal and bladder cancer from The Cancer Genome Atlas (TCGA) and in one EGFRL858R TRACERx patient with NSCLC (Extended Data Fig. 3d). The gene discussed is APOBEC3B; the disease is urinary bladder carcinoma.