The equivalent of the A3B-driven mutation in humans (Ptprs_mut1, D138N; Extended Data Fig. 3c) was identified in tumors of patients with lung, colorectal and bladder cancer from The Cancer Genome Atlas (TCGA) and in one EGFRL858R TRACERx patient with NSCLC (Extended Data Fig. 3d). This evidence concerns the gene APOBEC3B and non-small cell lung carcinoma.