To validate our findings from mouse models, long-term cell viability with targeted therapy was assessed in established human cell line models of oncogenic EGFRmut and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) lung adenocarcinoma with CRISPR-mediated A3B depletion. This evidence concerns the gene APOBEC3B and lung adenocarcinoma.