To further examine the impact of prefrontal PV activation on behavior in PCP model, we performed the open field test in chronic PCP-treated PV-Cre mice that previously received AAV-hSyn-DIO-mCherry or AAV-hSyn-DIO-hM3D(Gq)-mCherry under olanzapine 7.5 mg/kg/day treatment. This evidence concerns the gene RIC8B and pneumocystosis.